A spectrofluorimetric method for the determination of pindolol in natural waters using various organic and cyclodextrin media

Autor: Mame Diabou Gaye-Seye, Mehmet A. Oturan, Jean-Jacques Aaron, Nihal Oturan, Lamine Cisse, Coumba Gueye
Přispěvatelé: Laboratoire Géomatériaux et Environnement (LGE ), Université Gustave Eiffel
Rok vydání: 2021
Předmět:
Zdroj: Environmental Science and Pollution Research
Environmental Science and Pollution Research, Springer Verlag, 2021, 28 (39), pp.55029-55040. ⟨10.1007/s11356-021-14801-w⟩
ISSN: 1614-7499
0944-1344
Popis: A simple, sensitive, and rapid spectrofluorimetric method was developed for the determination of the β-blocker pindolol. The native fluorescence of pindolol was measured in different organic solvents and in cyclodextrin aqueous media. The highest fluorescence signal was obtained in 2-propanol at λem = 303 nm with λex = 260 nm. Analytical figures of merit for the spectrofluorimetric determination of pindolol were satisfactory, with wide linear dynamic range (LDR) values of two orders of magnitude, and rather low limit of detection (LOD) values between 0.2 and 8.7 ng/mL. Moreover, the addition of cyclodextrins (HP-β-CD and β-CD) in aqueous media enhanced the fluorescence of pindolol. In addition, the inclusion complexes of pindolol with cyclodextrins were investigated and the stability constants of complexes were calculated by means of the method of nonlinear regression (NLR). The method was successfully applied to the analysis of tap water and natural water samples, spiked with pindolol.
Databáze: OpenAIRE
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