Assessment of the degradation rates and effectiveness of different coated Mg-Zn-Ca alloy scaffolds for in vivo repair of critical-size bone defects
| Autor: | Chang-Long Zhou, Huanxin Xie, Dewei Zhao, Nan Zhang, Yuefei Wang, Jiahui Yang, Jinpeng Zhuang, Yunfeng Wu, Yaming Wang, Jinglong Yan, Ye Ji, Na Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Scaffold Materials science X-ray microtomography Biocompatibility Bone pathology 0206 medical engineering Biomedical Engineering Biophysics Biocompatible Materials Ulna Bioengineering 02 engineering and technology Bone healing engineering.material Bone and Bones Biomaterials Fractures Bone Coating Osteogenesis Alloys medicine Animals Magnesium Surgical repair Minerals Tissue Scaffolds X-Rays Reproducibility of Results X-Ray Microtomography Fluoresceins 021001 nanoscience & nanotechnology 020601 biomedical engineering Biomechanical Phenomena Zinc medicine.anatomical_structure Clinical Applications of Biomaterials engineering Calcium Female Cortical bone Gases Rabbits Stress Mechanical 0210 nano-technology Hydrogen Biomedical engineering |
| Zdroj: | Journal of Materials Science. Materials in Medicine |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-018-6145-2 |
| Popis: | Surgical repair of bone defects remains challenging, and the search for alternative procedures is ongoing. Devices made of Mg for bone repair have received much attention owing to their good biocompatibility and mechanical properties. We developed a new type of scaffold made of a Mg-Zn-Ca alloy with a shape that mimics cortical bone and can be filled with morselized bone. We evaluated its durability and efficacy in a rabbit ulna-defect model. Three types of scaffold-surface coating were evaluated: group A, no coating; group B, a 10-μm microarc oxidation coating; group C, a hydrothermal duplex composite coating; and group D, an empty-defect control. X-ray and micro-computed tomography(micro-CT) images were acquired over 12 weeks to assess ulnar repair. A mechanical stress test indicated that bone repair within each group improved significantly over time (P |
| Databáze: | OpenAIRE |
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