Marked toxicity of Albizia bernieri extracts on embryo–larval development in the medaka fish (Oryzias latipes)
| Autor: | Ranjana Randrianarivo, Simone Puiseux Dao, Victor Jeannoda, Chakib Djediat, Anne Offroy, Lengo Mambu, Marc Edery, Danielle Rakoto, Lovarintsoa Judicael Randriamampianina |
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| Rok vydání: | 2013 |
| Předmět: |
Embryo
Nonmammalian animal structures Oryzias Spermine Albizzia Toxicology chemistry.chemical_compound Toxicity Tests Botany Animals Ecotoxicology Cerebrum Larva Dose-Response Relationship Drug biology Plant Extracts fungi Embryo Albizia biology.organism_classification Biochemistry chemistry Phytochemical embryonic structures Toxicity Embryo Loss Female |
| Zdroj: | Toxicon. 64:29-35 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2012.12.012 |
| Popis: | Previous phytochemical studies have shown that the plants of the Albizia genus (Fabaceae) contain bioactive saponins, lignans, spermine alkaloids, flavonoids, glycosides phenols and pyridoxine derivatives. Their extracts sometimes display medical properties, but can have also toxic effects. The purpose of our study was to determine the in vivo toxicity of Albizia bernieri seeds in the experimental model of the medaka fish embryo, which is recommended for use in toxicity studies. Our results show clearly that incubating the embryos or larvae of the medaka fish in a medium containing A. bernieri extracts caused a dose-dependent reduction in embryo or larvae survival. Embryos exposed to an extract of A. bernieri displayed cerebral lesions, such as cell lysis and the emergence of lysosomes in the glial tissue. We conclude that when comparing with data obtained with different plant extracts tested on medaka development in our laboratory, A. bernieri displays an unusually high toxicity. Focussing on the cerebral target as well as the fish behaviour could bring more specific informations. |
| Databáze: | OpenAIRE |
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