Experimental infection of specific pathogen-free New Zealand White rabbits with five strains of amyxomatous myxoma virus
| Autor: | Dominique Cassart, C. Boucraut-Baralon, Freddy Coignoul, Henri Vindevogel, Didier Marlier |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Virulence Myxoma virus Antibodies Viral Polymerase Chain Reaction Virus Pathology and Forensic Medicine Species Specificity Myxomatosis Infectious Neutralization Tests biology.domesticated_animal medicine Animals Fluorescent Antibody Technique Indirect Lung Specific-pathogen-free Myxomatosis General Veterinary biology Inoculation Eyelids biology.organism_classification Epizootiology medicine.disease Virology Specific Pathogen-Free Organisms Disease Models Animal DNA Viral Rabbits European rabbit Lung Diseases Interstitial |
| Zdroj: | Journal of comparative pathology. 121(4) |
| ISSN: | 0021-9975 |
| Popis: | Myxomatosis1999 Harcourt Publishers Ltdis a specific disease of the European rabbit ( Copyright Oryctolagus cuniculus ) due to a virus belonging to the genus Leporipoxvirus . Forty-seven years after its deliberate introduction into Europe, the clinical aspects and the epizootiology of myxomatosis have changed. Two forms (nodular and amyxomatous) of the disease have been identified to date. A comparative study was made of the clinical signs, pathogenesis and gross lesions observed in male specific pathogen-free New Zealand White rabbits inoculated with five strains of amyxomatous myxoma virus. All five strains induced the characteristic amyxomatous myxomatosis clinical syndrome with clinical signs that differed only in intensity. The varying clinical intensity, together with the results of virological examination question the virulence of at least three of the five strains. Genomic analysis confirmed that the five strains came from the Lausanne strain introduced in 1952 in France and not from an unnoticed introduction of a Californian strain of myxoma virus. No link was found between the amyxomatous myxoma virus strains and the SG33 vaccine strain. 1999 W.B. Saunders and Company Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect