Inspiratory muscle responses to sudden airway occlusion in chronic obstructive pulmonary disease
| Autor: | Simon C. Gandevia, Anna L. Hudson, Isabella Epiu, Chanelle Basha, Claire L. Boswell-Ruys, Jane E. Butler, Sean N J Archer |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Pulmonary disease Respiratory physiology Reflex inhibition Airway occlusion Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Reflex medicine Humans 030212 general & internal medicine Aged Aged 80 and over Sleep Apnea Obstructive COPD business.industry Inspiratory muscle Middle Aged medicine.disease Respiratory Muscles respiratory tract diseases Airway Obstruction 030228 respiratory system Cardiology business |
| Zdroj: | Journal of Applied Physiology. 131:36-44 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00017.2021 |
| Popis: | Brief airway occlusion produces a potent reflex inhibition of inspiratory muscles that is thought to protect against aspiration. Its duration is prolonged in asthma and obstructive sleep apnea. We assessed this inhibitory reflex (IR) in chronic obstructive pulmonary disease (COPD). Reflex responses to brief (250 ms) inspiratory occlusions were measured in 18 participants with moderate to severe COPD (age 73 ± 11 yr) and 17 healthy age-matched controls (age 72 ± 6 yr). We compared the incidence and properties of the IR between groups. Median eupneic preocclusion electromyographic activity was higher in the COPD group than controls (9.4 μV vs. 5.2 μV |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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