Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy
Autor: | Keith K. Lau, Robert J. Wyatt, John T. Sanders, Zina Moldoveanu, Bruce A. Julian, Sabahat Afshan, T. Matthew Eison, Oulimata Kane, M. Colleen Hastings, Jan Novak |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Urinary protein
medicine.medical_specialty Article Subject 030232 urology & nephrology lcsh:RC870-923 Gastroenterology Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine fluids and secretions stomatognathic system Internal medicine Biopsy Medicine 030212 general & internal medicine Creatinine Proteinuria Adult patients medicine.diagnostic_test business.industry Mean age medicine.disease lcsh:Diseases of the genitourinary system. Urology chemistry Nephrology Cohort Immunology medicine.symptom business Research Article |
Zdroj: | International Journal of Nephrology International Journal of Nephrology, Vol 2012 (2012) |
ISSN: | 2090-2158 2090-214X |
Popis: | Introduction. Percentage of galactose-deficient IgA1 (Gd-IgA1) relative to total IgA in serum was recently reported to correlate with proteinuria at time of sampling and during follow-up for pediatric and adult patients with IgA nephropathy. We sought to determine whether this association exists in another cohort of pediatric patients with IgA nephropathy.Methods. Subjects were younger than 18 years at entry. Blood samples were collected on one or more occasions for determination of serum total IgA and Gd-IgA1. Gd-IgA1 was expressed as serum level and percent of total IgA. Urinary protein/creatinine ratio was calculated for random specimens. Spearman’s correlation coefficients assessed the relationship between study variables.Results. The cohort had 29 Caucasians and 11 African-Americans with a male : female ratio of 1.9 : 1. Mean age at diagnosis was 11.7 ± 3.7 years. No statistically significant correlation was identified between serum total IgA, Gd-IgA1, or percent Gd-IgA1 versus urinary protein/creatinine ratio determined contemporaneously with biopsy or between average serum Gd-IgA1 or average percent Gd-IgA1 and time-average urinary protein/creatinine ratio.Conclusion. The magnitude of proteinuria in this cohort of pediatric patients with IgA nephropathy was influenced by factors other than Gd-IgA1 level, consistent with the proposed multi-hit pathogenetic pathways for this renal disease. |
Databáze: | OpenAIRE |
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