Significance of Cytoplasmic Inclusions in Lupus Nephritis
| Autor: | E. Grishman, E Marquet, V. S. Venkataseshan |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Cytoplasmic inclusion Kidney Glomerulus Lupus nephritis Immunoglobulins Peritubular capillary Basement Membrane Pathology and Forensic Medicine Structural Biology Humans Medicine Recent onset Inclusion Bodies business.industry Immune deposits Middle Aged medicine.disease Lupus Nephritis Microscopy Electron Kidney Tubules Microscopy Fluorescence Immunology Female Endothelium Vascular business |
| Zdroj: | Ultrastructural Pathology. 15:1-14 |
| ISSN: | 1521-0758 0191-3123 |
| DOI: | 10.3109/01913129109021300 |
| Popis: | The report describes 22 cases of lupus nephritis (20 diffuse and 2 mesangial) showing frequent tubuloreticular inclusions (TRI) in the glomerular and peritubular capillary endothelial cells as well as cylindric confronting cisternae (CCC) mainly in interstitial infiltrating cells. Ten other cases of lupus nephritis that were actively treated or were in the sclerosing stage and did not show CCC were also studied. The presence of cytoplasmic inclusions correlated with various clinical and histologic parameters. Cytoplasmic inclusions, especially CCC, are associated with clinically active, minimally treated renal disease of recent onset and histologically with active diffuse glomerular and acute interstitial lupus nephritis with many immune deposits. |
| Databáze: | OpenAIRE |
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