Successful Unrelated Cord Blood Transplantation For Homozygous α-Thalassemia
| Autor: | Alfred C. Grovas, Elizabeth I. Thompson, Phyllis I. Warkentin, Peter F. Coccia, Terrence L. Zach, Burak Gumuscu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Resuscitation Iron Overload Thalassemia Hemosiderosis Cord Blood Stem Cell Transplantation Gastroenterology Phlebotomy alpha-Thalassemia Hydrops fetalis Internal medicine medicine Humans Blood Transfusion Child business.industry Homozygote Deferasirox Hematology medicine.disease Chelation Therapy Transplantation Treatment Outcome Oncology Pediatrics Perinatology and Child Health Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 35:570-572 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0b013e31827e7f6a |
| Popis: | A now 10-year-old Laotian female was delivered at 30-week gestation by cesarean section because of severe hydrops. Fetal blood sampling revealed homozygous α-thalassemia. After immediate resuscitation, the infant was supported with frequent red cell transfusions. At 44 months of age, she received a 5 of 6 human leukocyte antigen-matched unrelated cord blood transplantation. She was treated with phlebotomy and chelation therapy with Deferasirox for correction of hemosiderosis and has been transfusion-independent since 41 days after transplant. She is currently 6 years after transplantation with stable, 100% donor engraftment, resolved iron overload, and normal growth and development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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