Stress of the Endoplasmic Reticulum of Neurons in Stroke Can Be Maximally Limited by Combined Exposure to Hypercapnia and Hypoxia
| Autor: | A. S. Zabrodina, P. P. Tregub, Yu. G. Motin, M. E. Nagibaeva, V. P. Kulikov |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Endoplasmic Reticulum General Biochemistry Genetics and Molecular Biology Hypercapnia 03 medical and health sciences 0302 clinical medicine medicine Animals Rats Wistar Transcription factor Neurons biology Chemistry Endoplasmic reticulum General Medicine Cell Hypoxia Cell biology Rats Stroke 030104 developmental biology Chaperone (protein) Anesthesia biology.protein medicine.symptom hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 161(4) |
| ISSN: | 1573-8221 |
| Popis: | We studied the expression of chaperone GRP-78 and transcription factor NF-kB during the development of ischemic tolerance of the brain after combined and isolated exposure to hypoxia and hypercapnia. Combined exposure to hypoxia and hypercapnia maximally increased the expression of chaperone GRP-78 and transcription factor NF-kB, while the formation of ischemia-induced tolerance under conditions of hypercapnic hypoxia can be associated with activation of adaptive stress mechanisms in the endoplasmic reticulum. Under these conditions, hypercapnia in combination with hypoxia is a priority factor for activation of GRP-78 and transcription factor NF-kB. |
| Databáze: | OpenAIRE |
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