Infection with respiratory syncytial virus and water-soluble components of cigarette smoke alter production of tumour necrosis factor α and nitric oxide by human blood monocytes
| Autor: | C. Caroline Blackwell, Steve D. Essery, Robert A. Elton, Donald M. Weir, Muhammad W. Raza, Marie Ogilvie |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment Immunology Inflammation Nitric Oxide Microbiology Monocytes Cell Line Nitric oxide Mice chemistry.chemical_compound Smoke Tobacco parasitic diseases Tumor Cells Cultured medicine Animals Humans Immunology and Allergy Respiratory system Mononegavirales biology Tumor Necrosis Factor-alpha business.industry Monocyte Respiratory disease Water General Medicine medicine.disease biology.organism_classification Plants Toxic Infectious Diseases medicine.anatomical_structure Cytokine chemistry Respiratory Syncytial Virus Human medicine.symptom business Respiratory tract |
| Zdroj: | FEMS Immunology & Medical Microbiology. 24:387-394 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.1999.tb01310.x |
| Popis: | Cigarette smoke and virus infections contribute to the pathogenesis and exacerbation of chronic obstructive pulmonary disease and asthma. The objective of this study was to examine the effects of a water-soluble cigarette smoke extract (CSE) and/or respiratory syncytial virus (RSV) infection on release from monocytes of the blood from donors of tumour necrosis factor alpha (TNF-alpha) and nitric oxide (NO). Both RSV infection and CSE stimulated TNF-alpha release from monocytes and there was an additive effect if both the agents were present. There was a decrease in NO release, but the effect was significant only with CSE or a combination of CSE and RSV infection. Interferon gamma significantly increased TNF-alpha release and cotinine significantly increased NO release. Nicotine decreased both TNF-alpha and NO responses. The general pattern observed for individual donors was increased TNF-alpha and decreased NO. The proportion of extreme responses with very high TNF-alpha and very low NO in the presence of both RSV and CSE increased to 20% compared with 5% observed with CSE or RSV alone. The results show that RSV infection and components of cigarette smoke elicit inflammatory responses that could contribute to damage to the respiratory tract and these individual factors could be more harmful in combination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text