From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists
| Autor: | Nigel P. Shankley, Matthew J. Tozer, S B Kalindjian, Elaine Anne Harper, Michael John Pether, G. F. Watt |
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| Rok vydání: | 1999 |
| Předmět: |
Guinea Pigs
Clinical Biochemistry Histamine Antagonists Pharmaceutical Science Biochemistry chemistry.chemical_compound Histamine receptor Drug Discovery Animals Receptors Histamine H3 Histamine H4 receptor Receptor Molecular Biology Sulfonamides Histamine N-methyltransferase Organic Chemistry Imidazoles Antagonist Kinetics Models Chemical chemistry Drug Design Molecular Medicine Amine gas treating Histamine H3 receptor Histamine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 9:1825-1830 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00272-3 |
| Popis: | Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues. |
| Databáze: | OpenAIRE |
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