Intraluminal peptide YY induces colonic absorption in vivo
| Autor: | Michael J. Zinner, Carson D. Liu, Todd R. Newton, David W. McFadden, Stanley W. Ashley |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Malabsorption Time Factors Colon Sodium Lumen (anatomy) chemistry.chemical_element Eating Dogs Enteral Nutrition Body Water Chlorides In vivo Internal medicine medicine Animals Peptide YY Water transport biology business.industry digestive oral and skin physiology Fissipedia Gastroenterology General Medicine medicine.disease biology.organism_classification Endocrinology chemistry Intestinal Absorption Female business Peptides Hormone |
| Zdroj: | Diseases of the colon and rectum. 40(4) |
| ISSN: | 0012-3706 |
| Popis: | INTRODUCTION: Peptide YY (PYY) is a 36 amino acid hormone released into the circulation and lumen of the intestine after a meal. Previous studies have shown that exogenous administration of intravenous PYY stimulates water and electrolyte absorption in both the small and large intestines. The purpose of this study was to examine the effects of intraluminal administration of PYY on colonic absorption of electrolytes and water. METHODS: Six conditioned 25-kg dogs had 20 cm of colonic Thiry-Vella fistulae surgically constructed under general anesthesia. After a two-week recovery period, the animals received intraluminal PYY at 600 pmol/kg/hour after a 90-minute steady-state basal period. The Thiry-Vella fistulae were perfused with an isotonic buffer solution containing [14C]polyethylene glycol as a volume marker. Ion and water transport were measured every 15 minutes. RESULTS: On intraluminal infusion of PYY, increased absorption of water, sodium, and chloride was observed in the colon. A twofold increase in absorption rates occurred compared with basal rates lasting more than one hour after cessation of intraluminal PYY (N = 6;P |
| Databáze: | OpenAIRE |
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