Relationship between diabetic retinopathy and diabetic nephropathy; A longitudinal follow-up study from a tertiary care unit of Karachi, Pakistan
| Autor: | Nida Mustafa, Asher Fawwad, Abdul Basit, Bilal Tahir, Anum Butt, Saima Askari, Muhammad Saif Ul haque |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism 030232 urology & nephrology 030209 endocrinology & metabolism Type 2 diabetes Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Internal Medicine Medicine Outpatient clinic Humans Diabetic Nephropathies Pakistan Longitudinal Studies Retrospective Studies Type 1 diabetes Diabetic Retinopathy business.industry Tertiary Healthcare Incidence General Medicine Diabetic retinopathy Middle Aged medicine.disease Prognosis Gestational diabetes Survival Rate Diabetes Mellitus Type 2 Disease Progression Female business Retinopathy Follow-Up Studies |
| Zdroj: | Diabetesmetabolic syndrome. 14(6) |
| ISSN: | 1878-0334 |
| Popis: | Objective To determine the development and progression of diabetic retinopathy in subjects with diabetic nephropathy. Methodology This retrospective longitudinal follow up study was conducted in outpatient department of Baqai Institute of Diabetology and Endocrinology (BIDE), a tertiary care diabetes unit of Karachi Pakistan, from January 2005 to December 2016. Type 2 diabetic subjects with newly diagnosed diabetic nephropathy (DN) and sex-age matched controls were identified from the electronic database of the institute, Health Management System (HMS). Subjects with type 1 diabetes, gestational diabetes and subjects with diabetic retinopathy (DR) at the baseline of both DN and non-DN group were excluded from the study. Statistical analyses were conducted by using SPSS version 20. Result Out of 3056 type 2 diabetic subjects, 2389 were with DN and 667 were without DN. The incidence of retinopathy was found to be 21.7 per 1000 person years. The incidence rate ratio (IRR) of 2.57 (1.92–3.43) showed that retinopathy was significantly higher in subjects with DN as compared to subjects without DN. Kaplan-Meier survival plot confirmed that subjects with DN had a worse diabetic retinopathy-free survival than subjects without DN. Conclusion Diabetic nephropathy is an independent risk factor for the development and progression of diabetic retinopathy. |
| Databáze: | OpenAIRE |
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