Rapid Infliximab Infusion in Children: A Multicenter Retrospective Cohort Study
| Autor: | Baruch Yerushalmi, Raffi Lev-Tzion, Dan Turner, Amit Assa, Oren Ledder, Avishay Lahad, Mira Friedman |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Adolescent MEDLINE Rapid infusion Inflammatory bowel disease Drug Administration Schedule Cohort Studies 03 medical and health sciences 0302 clinical medicine Gastrointestinal Agents Internal medicine medicine Humans skin and connective tissue diseases Child Infusions Intravenous Retrospective Studies 030203 arthritis & rheumatology business.industry Gastroenterology Retrospective cohort study medicine.disease Inflammatory Bowel Diseases Infliximab Multicenter study Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology business medicine.drug Cohort study |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 65(5) |
| ISSN: | 1536-4801 |
| Popis: | Pediatric data on rapid infliximab infusion are scarce. We report our experience with a 1-hour rapid infusion protocol, prescribed in 3 pediatric inflammatory bowel disease units during 18 to 26 months. Children treated with infliximab for inflammatory bowel disease using a standard 2- to 3-hour infusion protocol were switched to a 1-hour protocol if they had received at least 4 standard duration infusions with no infusion reactions, there was no recent dose increase and no more than 10 weeks had elapsed since the previous infusion. A total of 102 children received infliximab infusions during the study period (85 Crohn disease; mean age 14.6 ± 2.6 years) of whom 63 were switched to the rapid infusions. Seven patients on the rapid protocol (11%) and 6 patients on the standard protocol (15%) had infusion reactions (P = 0.55). Consistent with adult data, our study indicates that a 1-hour infliximab protocol in selected patients offers a safe alternative to the traditional 2- to 3-hour infusions. |
| Databáze: | OpenAIRE |
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