Protein clearance strategies for disease intervention
| Autor: | David Vilchez, Franziska Hommen, Saygın Bilican |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Proteasome Endopeptidase Complex Parkinson's disease Disease Bioinformatics Neurology and Preclinical Neurological Studies - Review Article Huntington's disease Autophagy medicine Humans Amyotrophic lateral sclerosis Biological Psychiatry Cancer Proteasome Ubiquitin business.industry Neurodegenerative Diseases medicine.disease Psychiatry and Mental health Proteostasis Neurology Proteolysis Parkinson’s disease Neurology (clinical) business Alzheimer’s disease Huntington’s disease |
| Zdroj: | Journal of Neural Transmission |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-021-02431-y |
| Popis: | Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin–proteasome system (UPS) and the autophagy-lysosome pathway. Growing evidence indicates that alterations in these major proteolytic mechanisms lead to a demise in proteostasis, contributing to the onset and development of distinct diseases. Indeed, dysregulation of the UPS or autophagy is linked to several neurodegenerative, infectious and inflammatory disorders as well as cancer. Thus, modulation of protein clearance pathways is a promising approach for therapeutics. In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention. |
| Databáze: | OpenAIRE |
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