The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
| Autor: | Sung Min You, Steven K. Grinspoon, Takara L. Stanley, David Mun, Hideo Makimura |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Overweight Arginine Growth Hormone-Releasing Hormone Biochemistry Body Mass Index Young Adult Endocrinology Thinness Internal medicine medicine Humans Aspartate Aminotransferases Obesity Adiposity business.industry Body Weight Biochemistry (medical) Liter Middle Aged Growth hormone–releasing hormone medicine.disease Body Height Somatropin Adipose Tissue Growth Hormone Body Composition medicine.symptom business Body mass index |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 93:4254-4260 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2008-1333 |
| Popis: | Context: The relative contribution of central adiposity vs. weight on GH response to stimulation testing in obesity is not known. Objective: We aimed to assess the contribution of weight and specific measures of central and peripheral adiposity to GH response to GHRH-arginine testing in lean, overweight, and obese men. Design: A total of 75 men [mean age, 44.3 ± 1.1 yr; body mass index (BMI), 28.8 ± 0.7 kg/m2] were investigated. Subjects were classified as lean (BMI < 25 kg/m2; n = 23), overweight (BMI ≥ 25 and Results: Peak stimulated GH was 36.4 ± 5.4, 16.6 ± 2.9, and 7.6 ± 0.9 μg/liter among lean, overweight, and obese subjects, respectively (P < 0.001 for all comparisons). Peak stimulated GH was 26.9 ± 3.4 μg/liter among subjects with WC less than 102 cm compared to 7.9 ± 0.9 μg/liter among subjects with WC of 102 cm or greater (P < 0.0001). Separate multivariate models using anthropometric, DEXA, and CT-derived measures of central adiposity demonstrated strong associations between peak stimulated GH and measures of central adiposity including WC, trunk fat by DEXA, and visceral adiposity by CT, controlling for age, BMI, and more general measures of adiposity. WC was independently associated with peak GH response to GHRH-arginine in a model including age, BMI, and hip circumference. In this model, BMI was no longer significant, and peak GH was reduced 1.02 μg/liter for each 1 cm increase in WC (P = 0.02). Conclusions: GH response to GHRH-arginine testing is reduced in both overweight and obese subjects and negatively associated with indices of central abdominal obesity including WC, trunk fat, and visceral adipose tissue. The use of waist circumference, as a surrogate for central adiposity, adds predictive information to the determination of GH response, independent of BMI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|