Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin
| Autor: | Mariana Henriques, Antonio Carlos Siani, Ligia Maria Marino Valente, Maria Amélia Lemos, Maria das Graças Henriques, Joaquim M.S. Cabral, Francisco Lemos |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Cell Survival medicine.drug_class Chemokine CXCL1 Immunology Pharmacology Nitric Oxide Anti-inflammatory Mice chemistry.chemical_compound Uncaria guianensis Anti-Allergic Agents medicine Animals Edema Pharmacology (medical) Pleurisy Cells Cultured Dose-Response Relationship Drug biology Plant Extracts Tumor Necrosis Factor-alpha business.industry Anti-Inflammatory Agents Non-Steroidal Zymosan respiratory system Eosinophil Pleural cavity medicine.disease biology.organism_classification Mice Inbred C57BL Plant Leaves Chemotaxis Leukocyte Disease Models Animal Ovalbumin Uncaria medicine.anatomical_structure chemistry Macrophages Peritoneal biology.protein Intercellular Signaling Peptides and Proteins business Chemokines CXC |
| Zdroj: | InflammoPharmacology. 14:48-56 |
| ISSN: | 1568-5608 0925-4692 |
| Popis: | Uncaria guianensis (Aublet) J. F. Gmelin is an herbal medicine from tropical areas of South and Central America. We investigated the anti-inflammatory and anti-allergic properties of an ethanolic extract of U. guianensis leaves, containing alkaloids, flavonoids and phenol carboxylic acids, as revealed by thin layer chromatography (TLC). Oral pre-treatment with U. guianensis inhibited zymosan-induced paw oedema (500 mg/paw) and pleural exudation (100 mg/kg) within 4 h (25-200 mg/kg). U. guianensis (100 mg/kg) inhibited total leukocyte and neutrophil numbers in the pleural cavity 4 h after zymosan stimulation. Pre-treatment with U. guianensis (100 mg/kg, p.o.) inhibited total leukocyte, neutrophil and eosinophil recruitment into the pleural cavity 24 h after LPS (250 ng/cavity, i.t.). Pre-treatment with U. guianensis inhibited paw oedema (25-200 mg/kg) induced by ovalbumin (OVA) within 1 h, and neutrophil and eosinophil recruitment into the mice pleural cavity 24 h after OVA (100 mg/kg). In vitro data revealed that U. guianensis impaired LPS-induced nitric oxide and CXCL8 generation by murine peritoneal macrophages, as well as OVA-induced interleukin-5 synthesis by previously sensitized spleen cells. These results demonstrate that U. guianensis leaves provide effective anti-inflammatory and anti-allergic activities. |
| Databáze: | OpenAIRE |
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