Adventitious agent contamination risk mitigation: engineering MMV virus resistance into CHO cells
| Autor: | Nan Lin, Henry George, Joaquina Mascarenhas, Lisa R. Burger, Delia Lyons, Audrey Chang, David Onions, David J. Pintel, Trissa Borgschulte, Ademola Kassim, Kevin J. Kayser |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
biology
Parvovirus business.industry Chinese hamster ovary cell food and beverages Virus resistance General Medicine Contamination biology.organism_classification Virology Animal origin General Biochemistry Genetics and Molecular Biology Virus Biotechnology Mouse minute virus Cell culture Medicine Oral Presentation business |
| Zdroj: | BMC Proceedings |
| ISSN: | 1753-6561 |
| Popis: | Background The introduction of animal origin free (AOF) media has significantly reduced the incidence of adventitious virus contamination in biological production systems. Nevertheless, contamination by the parvovirus Mouse Minute Virus (MMV) remains a continuing challenge. Although infrequent, infection of a fermenter can be catastrophic for a manufacturer, and can also have a potential impact on drug supply, patient safety and have regulatory implications. In this work, we evaluated engineering Chinese Hamster Ovary (CHO) cell lines to create a new host cell line that |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|