Antioxidant agents and physiological responses in adult epileptic patients treated with lamotrigine
| Autor: | Sakaewan Ounjaijean, Fergus Nicol, Pekka Kaipainen, Faik Atroshi, Paweł Zagrodzki, Tuomas Westermarck, Markus Kaski, Elżbieta Płonka-Półtorak, Henryk Bartoń, Jadwiga Kryczyk |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant GPX3 medicine.medical_treatment Urine Lamotrigine Antioxidants Selenium Young Adult 03 medical and health sciences Epilepsy chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans 030304 developmental biology Pharmacology 0303 health sciences Creatinine Superoxide Dismutase Triazines Chemistry Case-control study Deoxyguanosine General Medicine medicine.disease Ferric reducing ability of plasma 3. Good health Endocrinology 8-Hydroxy-2'-Deoxyguanosine Case-Control Studies Anticonvulsants Female 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pharmacological Reports. 65:99-106 |
| ISSN: | 1734-1140 |
| Popis: | Background The aim of our research was to evaluate some biochemical changes in blood during lamotrigine (LTG) monotherapy of adult patients with epilepsy, and to check possible associations between typical selenium status parameters and the frequency of seizures. Methods The study was performed by examining aspartate aminotransferase (AspAT), alanine aminotransferase (AlaAT), creatinine, ferric reducing ability of plasma (FRAP), serum uric acid (UA), uric-acid-independent FRAP (UAiFRAP), plasma glutathione peroxidase (GPX3), selenoprotein P (SelP), plasma superoxide dismutase (pSOD), 8-hydroxy-2’-deoxyguanosine (8-OHdG) in serum and urine, serum selenium (sSe) and zinc (sZn), in 22 adult patients with epilepsy and 22 healthy controls. Additionally, the levels of LTG were determined in patients. Results pSOD activity was higher in the study group (5.32 ± 1.24 U/ml) compared with the controls (4.05 ± 0.92 U/ml, p = 0.008). No other statistical difference between patients and controls was found. Conclusion Lack of difference in parameters other than SOD, particularly no difference in 8-OHdG concentrations between the patients treated with LTG compared to the control subjects suggests that these patients are at no particular risk of oxidative DNAdamage. In patients who are well or moderately well clinically controlled, selenium status parameters (sSe, GPX3, SelP) are not directly connected with the frequency of seizures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink