Taste and smell perception and quality of life during and after systemic therapy for breast cancer

Autor: H.W.M. van Laarhoven, A. Haringhuizen, C. S. Kelfkens, N. Buist, E. E. Posthuma, Dirkje W. Sommeijer, M. van den Berg, Sanne Boesveldt, Y. de Vries, C. de Graaf, J. Th C.M. de Kruif, Renate M. Winkels, Ellen Kampman, S. Grosfeld
Přispěvatelé: Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Oncology, Neurology, CCA - Cancer Treatment and quality of life, VU University medical center, Epidemiology and Data Science, Methodology and Applied Biostatistics, APH - Health Behaviors & Chronic Diseases
Rok vydání: 2017
Předmět:
Cancer Research
Taste
Nutrition and Disease
medicine.medical_treatment
Systemic therapy
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
Olfaction Disorders
0302 clinical medicine
Breast cancer
Quality of life
Trastuzumab
Voeding en Ziekte
Surveys and Questionnaires
030212 general & internal medicine
Sensory Science and Eating Behaviour
Human Nutrition & Health
Humane Voeding & Gezondheid
Middle Aged
Smell
Oncology
030220 oncology & carcinogenesis
Female
medicine.symptom
psychological phenomena and processes
Taste loss
medicine.drug
Adult
medicine.medical_specialty
Breast Neoplasms
Dysgeusia
03 medical and health sciences
SDG 3 - Good Health and Well-being
Herceptin
Internal medicine
medicine
Chemotherapy
Humans
VLAG
business.industry
Cancer
medicine.disease
Sensoriek en eetgedrag
Quality of Life
business
Zdroj: Breast Cancer Research and Treatment, 170, 1, pp. 27-34
Breast Cancer Research and Treatment, 170(1), 27-34
Breast Cancer Research and Treatment, 170, 27-34
de Vries, Y C, Boesveldt, S, Kelfkens, C S, Posthuma, E E, van den Berg, M M G A, de Kruif, J T C M, Haringhuizen, A, Sommeijer, D W, Buist, N, Grosfeld, S, de Graaf, C, van Laarhoven, H W M, Kampman, E & Winkels, R M 2018, ' Taste and smell perception and quality of life during and after systemic therapy for breast cancer ', Breast Cancer Research and Treatment, vol. 170, no. 1, pp. 27-34 . https://doi.org/10.1007/s10549-018-4720-3
Breast cancer research and treatment, 170(1), 27-34. Springer New York
de Vries, Y C, Boesveldt, S, Kelfkens, C S, Posthuma, E E, van Den Berg, M M G A, de Kruif, J T C M, Haringhuizen, A, Sommeijer, D W, Buist, N, Grosfeld, S, de Graaf, C, van Laarhoven, H W M, Kampman, E & Winkels, R M 2018, ' Taste and smell perception and quality of life during and after systemic therapy for breast cancer ', Breast Cancer Research and Treatment, vol. 170, no. 1, pp. 27-34 . https://doi.org/10.1007/s10549-018-4720-3
Breast Cancer Research and Treatment 170 (2018) 1
Breast Cancer Research and Treatment, 170(1), 27-34. Springer New York
ISSN: 1573-7217
0167-6806
DOI: 10.1007/s10549-018-4720-3
Popis: Contains fulltext : 193416.pdf (Publisher’s version ) (Open Access) PURPOSE: The purpose of the study was to assess self-reported taste and smell perception after chemotherapy in breast cancer patients compared with women without cancer, and to assess whether taste and smell perception is associated with quality of life after the end of chemotherapy. METHODS: We included 135 newly diagnosed breast cancer patients who completed chemotherapy and 114 women without cancer. Questionnaires on taste, smell, and quality of life were completed shortly after and 6 months after chemotherapy (patients) or at two moments with 6 months' time window in between (comparisons). RESULTS: Self-reported taste and smell perception were significantly lower in patients shortly after chemotherapy compared to the comparison group. Most patients recovered 6 months after chemotherapy, although patients who were still receiving trastuzumab then reported a lower taste and smell perception compared to patients who were not. A lower self-reported taste and smell were statistically significantly associated with a worse quality of life, social, emotional, and role functioning shortly after chemotherapy. Six months after chemotherapy, taste and smell were statistically significantly associated with quality of life, social and role functioning, but only in patients receiving trastuzumab. CONCLUSIONS: Most taste and smell alterations recovered within 6 months after the end of chemotherapy for breast cancer, but not for patients receiving trastuzumab. These results highlight the importance of monitoring taste and smell alterations during and after treatment with chemotherapy and trastuzumab, as they may impact quality of life.
Databáze: OpenAIRE
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