The impact of bilingualism on brain structure and function in Huntington's disease
| Autor: | Valle Camacho, Diego Alfonso López-Mora, Ignasi Carrió, Alejandro Fernández-León, Jesús Pérez-Pérez, Frederic Sampedro, Saul Martinez-Horta, Beatriz Gómez-Ansón, Jaime Kulisevsky, Gloria Andrea Lozano-Martinez, Andrea Horta-Barba, Javier Pagonabarraga, Andrea Moreu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Bilingualism Cognitive reserve Brain Structure and Function Inferior frontal gyrus Multilingualism Neuroprotection Executive Function 03 medical and health sciences 0302 clinical medicine Cognitive Reserve Huntington's disease medicine Humans VBM Anterior cingulate cortex Cerebral Cortex business.industry Neurodegeneration Cognition Middle Aged Protective Factors medicine.disease Magnetic Resonance Imaging 18F-FDG Inhibition Psychological Huntington Disease 030104 developmental biology medicine.anatomical_structure Neurology Positron-Emission Tomography Female Neurology (clinical) Geriatrics and Gerontology business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PARKINSONISM & RELATED DISORDERS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2018.09.017 |
| Popis: | Introduction Bilingualism exerts neuroprotective effects against neurodegeneration. In Huntington's disease (HD), the systems involved in bilingual control show early compromise, but the effect of bilingualism on the course of HD is unknown. Methods We addressed the impact of livelong use of bilingualism on the clinical features, brain structure and function in 30 early-mild stage HD patients. Using voxel-wise regression analysis, we explored the effect of levels of use of bilingualism on grey-matter volume (GMV) and 18F-FDG metabolism. Results Higher use of bilingualism was associated with better performance in inhibitory control and set-shifting independently of age and education and with higher GMV in the inferior frontal gyrus. 18F-FDG data revealed a significant effect on multiple fronto-temporal regions, specifically, in the dorsal anterior cingulate cortex, the anterior insula, the ventromedial orbital prefrontal cortex and the inferior frontal gyrus. These changes contributed to better inhibitory control and set-shifting and to more preserved motor and functional capacity. Conclusion In HD, lifelong use of bilingualism is associated with structural and metabolic brain changes that have an impact on cognition, movement and functionality. These findings highlight the importance of stimulating cognitive and brain reserve in HD and in other neurodegenerative conditions. |
| Databáze: | OpenAIRE |
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