Vitamin D intake and risk of CVD and all-cause mortality: evidence from the Caerphilly Prospective Cohort Study

Autor: Peter Creighton Elwood, John R. Cockcroft, Jing Guo, D.I. Givens, Julie A. Lovegrove, Janet Elizabeth Pickering
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
Medicine (miscellaneous)
Nutritional Status
030209 endocrinology & metabolism
Blood Pressure
Type 2 diabetes
030204 cardiovascular system & hematology
Logistic regression
Gastroenterology
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
Longitudinal Studies
Prospective Studies
Mortality
Vitamin D
Prospective cohort study
Stroke
Triglycerides
Nutrition and Dietetics
Cholesterol
business.industry
Cholesterol
HDL
Public Health
Environmental and Occupational Health
Cholesterol
LDL
Middle Aged
medicine.disease
United Kingdom
Pulse pressure
Diet
Blood pressure
Endocrinology
Cross-Sectional Studies
chemistry
Diabetes Mellitus
Type 2
Cardiovascular Diseases
business
Biomarkers
Follow-Up Studies
Zdroj: Public health nutrition. 20(15)
ISSN: 1475-2727
1368-9800
Popis: ObjectiveProspective data on the associations between vitamin D intake and risk of CVD and all-cause mortality are limited and inconclusive. The aim of the present study was to investigate the associations between vitamin D intake and CVD risk and all-cause mortality in the Caerphilly Prospective Cohort Study.DesignThe associations of vitamin D intake with CVD risk markers were examined cross-sectionally at baseline and longitudinally at 5-year, 10-year and >20-year follow-ups. In addition, the predictive value of vitamin D intake for CVD events and all-cause mortality after >20 years of follow-up was examined. Logistic regression and general linear regression were used for data analysis.SettingParticipants in the UK.SubjectsMen (n452) who were free from CVD and type 2 diabetes at recruitment.ResultsHigher vitamin D intake was associated with increased HDL cholesterol (P=0·003) and pulse pressure (P=0·04) and decreased total cholesterol:HDL cholesterol (P=0·008) cross-sectionally at baseline, but the associations were lost during follow-up. Furthermore, higher vitamin D intake was associated with decreased concentration of plasma TAG at baseline (P=0·01) and at the 5-year (P=0·01), but not the 10-year examination. After >20 years of follow-up, vitamin D was not associated with stroke (n72), myocardial infarctions (n142), heart failure (n43) or all-cause mortality (n281), but was positively associated with increased diastolic blood pressure (P=0·03).ConclusionsThe study supports associations of higher vitamin D intake with lower fasting plasma TAG and higher diastolic blood pressure.
Databáze: OpenAIRE
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