| Popis: |
SUMMARY Four chemotherapeutic trials in Iran with the babesicide 3,3-bis-(2-imidazolin-2-yl) carbanilide dihydrochloride (Imidocarb dihydrochloride) are reported. Subcutaneous administration at a dose of 1 mg/kg proved highly effective in controlling experimental infection with a local virulent strain of Babesia bigemina in calves. While treated calves were apparently sterilized of the infection, they subsequently (100 days) were resistant to clinical re-infection despite the development of a low parasitaemia. No toxic effects attributable to the administration of the therapeutic dose of 1 mg/kg Imidocarb dihydrochloride were observed. Only mild and transient side effects were observed at 5 mg/kg and at 10 mg/kg; one of four calves died 12 days after the injection. The compound was considered to have a satisfactory therapeutic index and was shown to be less toxic and more effective in the treatment of B. bigemina infection than the therapeutic N,N -(dimethylquinolylium-methylsulphate-6-)-urea (Acaprin), currently available in Iran. |
