Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis
| Autor: | Victor Navarro, María Yolanda Rios, M. Ángeles Ramírez-Cisneros, Enrique Salazar-Rios |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Staphylococcus aureus
Lactams Stereochemistry Pharmaceutical Science 010402 general chemistry medicine.disease_cause Crystallography X-Ray 01 natural sciences Plant Roots Aristolochia Analytical Chemistry Anti-Infective Agents Drug Discovery medicine Pharmacology biology 010405 organic chemistry Chemistry Organic Chemistry biology.organism_classification Sulfur containing Antimicrobial 0104 chemical sciences Complementary and alternative medicine Natural source Molecular Medicine Sesquiterpenes Sulfur |
| Zdroj: | Journal of natural products. 80(12) |
| ISSN: | 1520-6025 |
| Popis: | Six new compounds, aristoloxazine A (1), aristoloxazine B (2), 7-methoxytaliscanine (3), humul-7-en-1,4,11-triol (4), 8-hydroxy-β-logipinene (5), and 1β-hydroxy-4(14)-eudesmene (6), corresponding to two sulfur-containing aristoloxazines (1 and 2), an aristolactam (3), and three sesquiterpenes (4–6) were isolated, along with 26 known compounds, from the roots of Aristolochia orbicularis. The structures of the new compounds were established based on their spectroscopic and spectrometric data and in the case of aristoloxazine A (1) by single-crystal X-ray crystallography. This is the first report of sulfur-containing aristoloxazines from a natural source. Furthermore, aristoloxazine A (1) was found to possess potent in vitro antimicrobial activity against all resistant Staphylococcus aureus and several fungal strains in which it was evaluated. |
| Databáze: | OpenAIRE |
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