Striatal Dopamine Transporter Spect Quantification: Head-To-Head Comparison Between Two Three-Dimensional Automatic Tools
| Autor: | Dario Arnaldi, Silvia Morbelli, Stefano Raffa, Selene Capitanio, Federico Massa, Laura Filippi, Andrea Chincarini, Maria Isabella Donegani, Alberto Miceli, Eugenia Cella, Flavio Nobili |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Striatal dopamine business.industry lcsh:R895-920 Parkinsonism Putamen Short Communication Gold standard (test) BasGanV2 medicine.disease Semi-quantification Datquant® Correlation Text mining Rating scale SPECT Dopamine transporter Medicine Radiology Nuclear Medicine and imaging Parkinson business Nuclear medicine Cardiac imaging |
| Zdroj: | EJNMMI Research EJNMMI Research, Vol 10, Iss 1, Pp 1-8 (2020) |
| DOI: | 10.21203/rs.3.rs-38885/v3 |
| Popis: | Purpose Our aim was to compare a widely distributed commercial tool with an older free software (i) one another, (ii) with a clinical motor score, (iii) versus reading by experts. Procedures We analyzed consecutive scans from one-hundred and fifty-one outpatients submitted to brain DAT SPECT for a suspected parkinsonism. Images were post-processed using a commercial (Datquant®) and a free (BasGanV2) software. Reading by expert was the gold standard. A subset of patients with pathological or borderline scan was evaluated with the clinical Unified Parkinson’s Disease Rating Scale, motor part (MDS-UPDRS-III). Results SBR, putamen-to-caudate (P/C) ratio, and both P and C asymmetries were highly correlated between the two software with Pearson’s ‘r’ correlation coefficients ranging from .706 to .887. Correlation coefficients with the MDS-UPDRS III score were higher with caudate than with putamen SBR values with both software, and in general higher with BasGanV2 than with Datquant®. Datquant® correspondence with expert reading was 84.1% (94.0% by additionally considering the P/C ratio as a further index). BasGanV2 correspondence with expert reading was 80.8% (86.1% by additionally considering the P/C ratio). Conclusions Both Datquant® and BasGanV2 work reasonably well and similarly one another in semi-quantification of DAT SPECT. Both tools have their own strength and pitfalls that must be known in detail by users in order to obtain the best help in visual reading and reporting of DAT SPECT. |
| Databáze: | OpenAIRE |
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