(-)-Carvone: antispasmodic effect and mode of action
| Autor: | Damião P. de Souza, Fábia Valéria Menezes Souza, Rosilene M. Marçal, Marcelly Barbosa da Rocha |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Contraction (grammar) Carbachol Potassium Channels medicine.drug_class Barium Compounds Guinea Pigs Drug Evaluation Preclinical Ileum Calcium channel blocker Cyclohexane Monoterpenes Pharmacology In Vitro Techniques Mentha spicata Potassium Chloride chemistry.chemical_compound Chlorides Drug Discovery medicine Animals Mode of action Chemistry Parasympatholytics Muscle Smooth General Medicine Calcium Channel Blockers medicine.anatomical_structure Verapamil Monoterpenes Antispasmodic Female Calcium Channels Histamine medicine.drug |
| Zdroj: | Fitoterapia. 85 |
| ISSN: | 1873-6971 |
| Popis: | (-)-Carvone is a monoterpene ketone found in spearmint (Mentha spicata var. crispa) essential oil that is widely used as an odor and flavor additive. An intestinal antispasmodic effect was recently reported for (-)-carvone, and it has been shown to be more potent than its (+)-antipode. The mechanism of (-)-carvone action in the intestines has not been investigated. To gain a better understanding of the (-)-carvone antispasmodic effect, we investigated its pharmacological effects in the guinea pig ileum. Terminal portions of the ileum were mounted for isotonic contraction recordings. The effect of (-)-carvone was compared with that of the classical calcium channel blocker (CCB) verapamil. In isolated ileal smooth muscle, (-)-carvone did not produce direct contractile or relaxation responses and did not modify electrically elicited contractions or low K(+)-evoked contractions. The submaximal contractions induced by histamine (p |
| Databáze: | OpenAIRE |
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