| Autor: |
James W. Tunnell, Parameshwaran Diagaradjane, Narasimhan Rajaram, Jon A. Schwartz, Kelly L. Gill-Sharp, J.D. Payne, James C. Wang, S.H. Cho, Sunil Krishnan, Henry Grady Rylander, Raiyan T. Zaman |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
IEEE J Sel Top Quantum Electron |
| Popis: |
This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500-800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed in vitro studies on tissue phantoms illustrating an accurate measurement of gold-silica nanoshell concentration within 12.6% of the known concentration. In vivo studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
