Diagnostic Value of a Group of MicroRNA Genes Hypermethylated in Ovarian Carcinoma

Autor:	Vitaly I. Loginov, N E Kuslinskii, D N Kushlinskii, I. V. Pronina, D. O. Utkin, L V Adamyan, E. A. Filippova, D. S. Khodyrev, Tatiana P. Kazubskaya, A M Burdennyi, Eleonora A. Braga
Rok vydání:	2018
Předmět:	0301 basic medicine Adult Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology Epigenesis Genetic Pathogenesis 03 medical and health sciences Ovarian carcinoma microRNA Biomarkers Tumor Medicine Humans Epigenetics Stage (cooking) Neoplasm Staging Ovarian Neoplasms 030102 biochemistry & molecular biology business.industry General Medicine Methylation DNA Methylation Middle Aged medicine.disease Gene Expression Regulation Neoplastic MicroRNAs Lymphatic Metastasis DNA methylation Cancer research Disease Progression CpG Islands Female business Ovarian cancer
Zdroj:	Bulletin of experimental biology and medicine. 166(2)
ISSN:	1573-8221
Popis:	The study was designed to determine genes of microRNAs hypermethylated in malignant ovarian tumors and to select new diagnostic and prognostic markers of the disease and effective system of markers. Using methyl-specific PCR and a representative sample of 54 ovarian cancer specimens, we determined 5 microRNA genes (MIR-34b/c, MIR-9-1, MIR-124-3, MIR-129-2, and MIR-107) hypermethylated in the majority of tumor samples in comparison with paired samples of histologically unchanged tissue (48-57% vs. 4-19%, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac75ad6e8235b0b11902331e909e39f https://pubmed.ncbi.nlm.nih.gov/30488208 Zobrazit plný text záznamu Full text from SpringerLink