Nefopam as an adjunct to intravenous patient-controlled analgesia after renal transplantation: a randomised trial
| Autor: | J.B. Park, Yong Seon Choi, So Yeon Kim, Yun Ho Roh, Kyu Ha Huh, Young Jun Oh |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Renal function Fentanyl chemistry.chemical_compound Young Adult Nefopam Medicine Humans Creatinine Pain Postoperative business.industry Cumulative dose Analgesia Patient-Controlled General Medicine Analgesics Non-Narcotic Middle Aged Kidney Transplantation Transplantation Anesthesiology and Pain Medicine Treatment Outcome chemistry Opioid Anesthesia Administration Intravenous Female business medicine.drug Intravenous Patient-Controlled Analgesia |
| Zdroj: | Acta anaesthesiologica Scandinavica. 59(8) |
| ISSN: | 1399-6576 |
| Popis: | Background Nefopam has been used as an adjuvant to opioid analgesia after operation. We investigated the efficacy of nefopam as an adjunct to fentanyl-based intravenous patient-controlled analgesia (IV PCA) on post-operative pain relief in patients undergoing renal transplantation. Methods Ninety-eight patients undergoing elective renal transplantation were randomised into two groups: nefopam or control groups. The former received nefopam (160 mg in 200 ml at a rate of 4 ml/h) whereas the latter received normal saline during the first 48 h after reperfusion of grafted kidney. Pain intensity scores, cumulative dose of fentanyl, and the incidence of adverse events were assessed at 1, 6, 12, 24, and 48 h post-operatively. Serum creatinine and estimated glomerular filtration rate were evaluated on post-operative days 1, 2, 4, and 7. Results The cumulative fentanyl consumption during the first 48 h after operation was 19% less in the nefopam group than that in the control group (1005 ± 344 μg vs. 1246 ± 486 μg, mean ± SD; P = 0.006). Pain intensity scores at rest and on coughing were significantly lower in the nefopam group throughout the first 12 and 48 h after operation, respectively. Adverse events and early graft function were comparable between the groups, except a significantly lower incidence of drowsiness observed in the nefopam group (4% vs. 21%, P = 0.027). Conclusion In combination with fentanyl PCA, nefopam reduced post-operative fentanyl consumption with superior analgesia after renal transplantation. |
| Databáze: | OpenAIRE |
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