Clinical Characteristics of Seven Patients with Lanthanum Phosphate Deposition in the Stomach
| Autor: | Junji Shiode, Masao Yoshioka, Masaya Iwamuro, Junichirou Nasu, Kazuhide Yamamoto, Soichiro Nose, Naoko Murakami, Hiroyuki Okada |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Asymptomatic Gastroenterology Phosphates 03 medical and health sciences Hyperphosphatemia 0302 clinical medicine Japan Lanthanum Renal Dialysis Internal medicine Internal Medicine Humans Medicine Dialysis Aged Retrospective Studies lanthanum carbonate medicine.diagnostic_test business.industry Esophagogastroduodenoscopy Stomach Continuous ambulatory peritoneal dialysis General Medicine Middle Aged medicine.disease Lanthanum carbonate medicine.anatomical_structure Endocrinology Kidney Failure Chronic Original Article Female 030211 gastroenterology & hepatology Hemodialysis medicine.symptom business chronic kidney disease medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.8720-16 |
| Popis: | Objective To analyze the clinical characteristics and endoscopic features of patients with lanthanum deposition in the stomach. Patients We retrospectively reviewed seven patients with lanthanum deposition in the stomach who were diagnosed at Okayama Saiseikai General Hospital. We investigated the patient sex, age at diagnosis, medical and medication histories, gastrointestinal symptoms, complications, presence or absence of gastric atrophy, and outcome. We also investigated any changes in the endoscopic features if previous endoscopic images were available. Results Seven patients (six males and one female) had lanthanum deposition. The median age was 65 years (range, 50-79 years). All patients had been undergoing dialysis (continuous ambulatory peritoneal dialysis in one patient, hemodialysis in six patients). The dialysis period ranged from 16 to 73 months (median, 52 months). The patients had all been taking lanthanum carbonate for a period ranging from 5 to 45 months (median, 27 months). Gastric atrophy was noted in 6 patients (85.7%). One patient had difficulty swallowing, and 1 other patient had appetite loss. The other 5 patients were asymptomatic. Endoscopic features included annular whitish mucosa (n = 4), diffuse whitish mucosa (n = 3), and whitish spots (n = 2). Five patients underwent multiple esophagogastroduodenoscopy. The endoscopic features were unchanged in 2 patients, whereas the whitish mucosa became apparent and spread during the course in 3 patients. Conclusion We identified 7 patients with lanthanum deposition in the stomach. All patients showed whitish lesions macroscopically. Although the pathogenicity of gastric lanthanum deposition is uncertain, lanthanum-related lesions in the stomach progressed during continuous lanthanum phosphate intake in several patients. |
| Databáze: | OpenAIRE |
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