Cytokines in Patients with Lung Cancer
| Autor: | N Matakorić, Zlata Beg-Zec, D Stojanović, Dubravka Matanić, F Milevoj-Ribić, Veljko Flego |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Necrosis medicine.medical_treatment Immunology Adenocarcinoma Gastroenterology Immune system Internal medicine Macrophages Alveolar Carcinoma medicine Humans Lung cancer BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine cancer cytokines lung Aged BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina Aged 80 and over Lung medicine.diagnostic_test Interleukin-6 Tumor Necrosis Factor-alpha business.industry Cancer General Medicine Middle Aged respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Bronchoalveolar lavage Cytokine Carcinoma Squamous Cell Cytokines Female medicine.symptom business Bronchoalveolar Lavage Fluid Interleukin-1 |
| Zdroj: | Scandinavian Journal of Immunology Volume 57 Issue 2 |
| ISSN: | 1365-3083 0300-9475 |
| Popis: | Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell-mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6, releasing capacity in patients with lung carcinoma and benign lung disease. A group of 41 patients were tested for the production of TNF-alpha, IL-1beta and IL-6 in bronchoalveolar lavage (BAL) and blood. The levels of cytokines in the lung cancer patients were: (1) in BAL - IL-6, 173 +/- 85 pg/ml ; TNF-alpha, 170 +/- 116 pg/ml ; and IL-1beta, 473 +/- 440 pg/ml ; (2) in the blood - IL-6, 197 +/- 53 pg/ml ; TNF-alpha, 311 +/- 202 pg/ml ; and IL-1beta, 915 +/- 239 pg/ml. Alveolar macrophages of the patients with a lung cancer secreted significantly more cytokines, IL-6 (P = 0.0004) and IL-1beta (P = 0.0047), than alveolar macrophages of the patients with a nonmalignant lung cancer. However, significantly lower levels of cytokine production by the BAL cells were found in patients with small cell lung cancer. This production decreased further in phase IV of nonsmall cell lung cancer |
| Databáze: | OpenAIRE |
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