Heart rate is associated with markers of fatty acid desaturation: the GOCADAN study
| Autor: | Peter M. Okin, Williams S. Harris, Jason G. Umans, William J. Howard, Barbara V. Howard, Richard B. Devereux, Sven O. E. Ebbesson, Lars O.E. Ebbesson, Anthony G. Comuzzie, Juan Carlos López-Alvarenga, Jean W. MacCluer, John M. Kennish, Maria Elizabeth Tejero, Sandra Laston, Charlotte R. Wenger, Richard R. Fabsitz |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Fatty Acid Desaturases Male medicine.medical_specialty Health (social science) lcsh:Arctic medicine. Tropical medicine Epidemiology Cross-sectional study lcsh:RC955-962 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Sudden death Cohort Studies 03 medical and health sciences chemistry.chemical_compound Basal (phylogenetics) 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Humans Original Research Article CVD risk factors Fatty acid metabolism business.industry Public Health Environmental and Occupational Health General Medicine Stepwise regression 3. Good health Red blood cell medicine.anatomical_structure Endocrinology Cross-Sectional Studies chemistry fatty acid metabolism Cardiovascular Diseases Inuit Inuit diet fatty acid metabolism CVD risk factors Female business diet Alaska Biomarkers Cohort study |
| Zdroj: | International Journal of Circumpolar Health, Vol 71, Iss 0, Pp 1-6 (2012) International Journal of Circumpolar Health; Vol 71 (2012) International Journal of Circumpolar Health |
| ISSN: | 2242-3982 1797-237X 1239-9736 |
| Popis: | Objectives: To determine if heart rate (HR) is associated with desaturation indexes as HR is associated with arrhythmia and sudden death. Study design: A community based cross-sectional study of 1214 Alaskan Inuit. Methods: Data of FA concentrations from plasma and red blood cell membranes from those ≥35 years of age (n=819) were compared to basal HR at the time of examination. Multiple linear regression with backward stepwise selection was employed to analyze the effect of the desaturase indexes on HR, after adjustment for relevant covariates. Results: The ∆ 5 desaturase index ( ∆ 5 -DI) measured in serum has recently been associated with a protective role for cardiovascular disease. This index measured here in plasma and red blood cells showed a negative correlation with HR. The plasma stearoyl-CoA-desaturase (SCD) index, previously determined to be related to cardiovascular disease (CVD) mortality, on the other hand, was positively associated with HR, while the ∆ 6 desaturase index ( ∆ 6 -DI) had no significant effect on HR. Conclusion: Endogenous FA desaturation is associated with HR and thereby, in the case of SCD, possibly with arrhythmia and sudden death, which would at least partially explain the previously observed association between cardiovascular mortality and desaturase activity. Keywords: Inuit; diet; fatty acid metabolism; CVD risk factors (Published: 19 March 2012) Citation: Int J Circumpolar Health 2012, 71 : 17343 - DOI: 10.3402/ijch.v71i0.17343 |
| Databáze: | OpenAIRE |
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