Cytomegalovirus DNAemia and risk of mortality in allogeneic hematopoietic stem cell transplantation: Analysis from the Spanish Hematopoietic Transplantation and Cell Therapy Group

Autor: Ana Julia Gonzalez-Huerta, Guiomar Bautista, Anabella Chinea, José Luis Piñana, Santiago Leguey Jiménez, Carlos Vallejo, Estela Giménez, Tamara Torrado, Albert Esquirol, Ildefonso Espigado, Javier López-Jiménez, Raquel Saldaña, María Ángeles Cuesta, Lourdes Vázquez, Rafael de la Cámara, María Suárez-Lledó, Carlos Solano, Montserrat Rovira, Montserrat Batlle, Aránzazu Bermúdez, Carmen Martín Calvo, Inmaculada Heras, Eliseo Albert, Ariadna Pérez, Pere Barba, David Fraile Navarro
Rok vydání: 2021
Předmět:
Oncology
medicine.medical_specialty
bone marrow
infection and infectious agents - viral
medicine.medical_treatment
Congenital cytomegalovirus infection
Cytomegalovirus
complication
Hematopoietic stem cell transplantation
030230 surgery
law.invention
Cell therapy
03 medical and health sciences
0302 clinical medicine
law
Internal medicine
hemic and lymphatic diseases
Risk of mortality
Immunology and Allergy
Medicine
Humans
Transplantation
Homologous
Pharmacology (medical)
Cumulative incidence
Polymerase chain reaction
Retrospective Studies
Transplantation
business.industry
Hematopoietic Stem Cell Transplantation
virus diseases
medicine.disease
practice
infectious
infection and infectious agents - viral: Cytomegalovirus (CMV) [bone marrow/hematopoietic stem cell transplantation
clinical research/practice
complication]
infectious
clinical research
Cohort
Cytomegalovirus Infections
DNA
Viral
hematopoietic stem cell transplantation
Cytomegalovirus (CMV)
business
Zdroj: American Journal of Transplantation
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
AMERICAN JOURNAL OF TRANSPLANTATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Fundacion Sancho el Sabio Fundazioa (FSS)
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
ISSN: 1600-6143
1600-6135
Popis: The net impact of cytomegalovirus (CMV) DNAemia on overall mortality (OM) and nonrelapse mortality (NRM) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a matter of debate. This was a retrospective, multicenter, noninterventional study finally including 749 patients. CMV DNA monitoring was conducted by real-time polymerase chain reaction (PCR) assays. Clinical outcomes of interest were OM and NRM through day 365 after allo-HSCT. The cumulative incidence of CMV DNAemia in this cohort was 52.6%. A total of 306 out of 382 patients with CMV DNAemia received preemptive antiviral therapy (PET). PET use for CMV DNAemia, but not the occurrence of CMV DNAemia, taken as a qualitative variable, was associated with increased OM and NRM in univariate but not in adjusted models. A subcohort analysis including patients monitored by the COBAS Ampliprep/COBAS Taqman CMV Test showed that OM and NRM were comparable in patients in whom either low or high plasma CMV DNA threshold (= 500 IU/mL) was used for PET initiation. In conclusion, CMV DNAemia was not associated with increased OM and NRM in allo-HSCT recipients. The potential impact of PET use on mortality was not proven but merits further research.
Databáze: OpenAIRE
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