Extradigestive Manifestation of Helicobacter Pylori Infection in Children and Adolescents

Autor: Frank Y H Lin, Philip M. Sherman
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Canadian Journal of Gastroenterology, Vol 19, Iss 7, Pp 421-424 (2005)
ISSN: 0835-7900
Popis: Helicobacter pylori infection fulfills each of Koch's postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recently, multiple publications have advocated a role for H pylori infection in causing a variety of extraintestinal manifestations. Many of these reports suffer from being case reports or case series without adequate controls. As a result, purported manifestations may simply be coincidental in nature. On the other hand, increasing evidence supports H pylori infection as a cause of sideropenic (refractory iron deficiency) anemia. Moderate evidence supports H pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field.
Databáze: OpenAIRE