Effect of endothelin on renal function in rats
| Autor: | Antonio López-Farré, Inmaculada Montañés, Inmaculada Millás, JoséM. López-Novoa |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Extraction ratio Renal function Blood Pressure PAH clearance urologic and male genital diseases Kidney Renal Circulation Internal medicine medicine Animals Pharmacology Chemistry Endothelins Rats Inbred Strains Filtration fraction Rats Urodynamics Endocrinology Renal blood flow Renal physiology Endothelin receptor Peptides Glomerular Filtration Rate |
| Zdroj: | European journal of pharmacology. 163(1) |
| ISSN: | 0014-2999 |
| Popis: | The effect of synthetic porcine endothelin on glomerular filtration rate, renal plasma flow and electrolyte excretion was studied in rats. Endothelin, 1 nmol/kg body weight given as a bolus, induced a transient decrease in glomerular filtration rate (72%) and in renal plasma flow (76%) as well as in sodium excretion, accompanied by a sustained increase in renal vascular resistance. This dose had no sustained effect on mean arterial pressure. It is concluded that endothelin induces a marked decrease in glomerular filtration rate and renal perfusion. This peptide could play a role in the alterations in renal function observed after renal injury. |
| Databáze: | OpenAIRE |
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