Clinical correlates of decreased plasma coenzyme Q10 levels in patients with multiple system atrophy
| Autor: | Tian Wang, Juan-Juan Du, Chao Gao, Shi-Shuang Cui, Sheng-Di Chen, Ya-Chao He, Pei Huang, Jun-Yi Shen, Yu-Yan Tan, Rao Fu, Yi-Qi Lin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Parkinson's disease Ubiquinone Disease Sensitivity and Specificity Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrophy stomatognathic system Internal medicine mental disorders parasitic diseases Humans Medicine In patient Aged Coenzyme Q10 Receiver operating characteristic business.industry Middle Aged Multiple System Atrophy medicine.disease nervous system diseases 030104 developmental biology nervous system Neurology chemistry Biomarker (medicine) Female Neurology (clinical) Geriatrics and Gerontology Differential diagnosis business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonism & Related Disorders. 57:58-62 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2018.07.017 |
| Popis: | Introduction Multiple system atrophy (MSA) is a progressive neurodegenerative disease. Recent studies revealed decreased coenzyme Q10 (COQ10) levels in the cerebellum and blood samples of MSA patients. But few studies focused on the associations of COQ10 with the clinical symptoms of MSA. In this study, we aimed to quantify plasma COQ10 and characterize its association with clinical features. Methods We recruited 40 patients with MSA, 30 patients with Parkinson's disease (PD), and 30 healthy participants. Plasma COQ10 was quantified by UPLC-MS. The basic demographic data, motor symptoms, and non-motor symptoms were also assessed. Results Plasma COQ10 levels were significantly different in MSA, PD, and controls (P = 0.001). Post-hoc analysis revealed plasma COQ10 levels in MSA patients were lower than that in controls after adjusting for age, gender, and total cholesterol (P = 0.001). COQ10 levels differentiated MSA patients from controls with modest accuracy (P = 0.001). A sensitivity of 40% and a specificity of 97.5% was calculated with the receiver operating characteristic curve. However, COQ 10 levels did not discriminate between the MSA and PD groups (P = 0.07). Plasma COQ10 levels were correlated with the severity of motor symptoms only in MSA-C patients (b = −0.025, P = 0.009). Conclusion The association between decreased COQ10 levels and the severity of motor symptoms in MSA-C patients promotes further research. Plasma COQ10 levels alone may not be a reliable MSA diagnostic biomarker, and cannot be considered a useful biomarker in the differential diagnosis of MSA vs PD. |
| Databáze: | OpenAIRE |
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