Investigation of surfactants suitable for stabilizing of latanoprost
| Autor: | Moriyuki Ohkuma, Akiko Ochiai, Kazumi Danjo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Preservative
genetic structures Pharmaceutical Science Micelle Benzalkonium chloride Hydrolysis chemistry.chemical_compound Surface-Active Agents Adsorption Pulmonary surfactant Drug Stability medicine Organic chemistry Latanoprost Alkyl Drug Packaging chemistry.chemical_classification Preservatives Pharmaceutical eye diseases chemistry Polyethylene Prostaglandins F Synthetic sense organs Ophthalmic Solutions Benzalkonium Compounds medicine.drug Nuclear chemistry |
| Zdroj: | International journal of pharmaceutics. 436(1-2) |
| ISSN: | 1873-3476 |
| Popis: | The content of latanoprost, a therapeutic drug for glaucoma, is likely to decrease in solution. In a previous study, we confirmed that this was associated with latanoprost adsorption to the container and hydrolysis of latanoprost, and established a formulation of latanoprost eye drop solution that can be stored at room temperature. In addition, we clarified that a surfactant added to the formulation stabilized latanoprost by forming complex micelle. In this study, we investigated the influence of structure of surfactants in the stabilization of latanoprost. Non-ionic surfactants involving the polyoxyethylene chain (additive mol number: 20 or more) and the straight-chain alkyl group, with an HLB of 15.0 or more, markedly inhibited a decrease in the latanoprost content and its degradation. These surfactants are soluble in the formulation of eye drop solution, leading to micelle formation even at a low concentration, and they are not influenced by the temperature. Therefore, they may exhibit marked stabilization effects. In addition, there was no influence on the stability of latanoprost when adding benzalkonium chloride, as a preservative, to a formulation involving these surfactants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect