Pancreas transplantation under alemtuzumab (Campath-1H) and tacrolimus: Correlation between low T-cell responses and infection
| Autor: | J. Britz, Ron Shapiro, Carol Bentlejewski, Henkie P. Tan, Amadeo Marcos, Adriana Zeevi, Richard Kowalski, Amit Basu, Deanna Blisard, Janice Glidewell, Cindy Smetanka, John J. Fung, Ngoc Thai, Kusum Tom |
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| Rok vydání: | 2007 |
| Předmět: |
Graft Rejection
Cellular immunity Antibodies Neoplasm medicine.medical_treatment T cell T-Lymphocytes Pancreas transplantation Antibodies Monoclonal Humanized Infections Tacrolimus Adenosine Triphosphate Monitoring Immunologic medicine Humans Alemtuzumab Transplantation business.industry Antibodies Monoclonal Immunosuppression Calcineurin medicine.anatomical_structure Immunology Biological Assay Pancreas Transplantation business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation. 82(12) |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Alemtuzumab induction and tacrolimus-based immunosuppression has been effective in pancreas transplantation. Despite the encouraging results of this minimalistic approach to immunosuppression, infection still remains a significant cause of morbidity. The Cylex ImmuKnow [corrected] assay was used in this study to compare pancreas recipient clinical states (stable, rejection, infection) with T cell responses. METHODS Blood samples were taken from pancreas recipients pretransplant and at approximately three-month intervals posttransplant for analysis of T cell responses. When possible, T cell responses were also quantified during changes in clinical status (infection or rejection). RESULTS A range between 100-300 ng/ml adenosine triphosphate (ATP) was found in stable patients (mean 194+/-123, n = 51) with good graft function and no infection or rejection. A low T cell response was highly correlated with infectious states. The fourteen patients with infections/posttransplant lymphoproliferative disease had a mean ATP of 48 ng/ml. Risk hazard analysis showed that patients with ATP levels |
| Databáze: | OpenAIRE |
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