Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: results from APL 93 trial
| Autor: | Pierre Fenaux, J F San Miguel, D. Cony Makhoul, J. de la Serna, Aspasia Stamatoulas, Anne Vekhoff, S. de Botton, Denis Caillot, Eulogio Conde, Martin F. Fey, Martine Gardembas, Hervé Dombret, Valérie Coiteux, Agnès Guerci, C. Gardin, Miguel A. Sanz, François Lefrère, Oumedaly Reman, L. Degos, Christine Chomienne, Sylvie Chevret |
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| Rok vydání: | 2002 |
| Předmět: |
Acute promyelocytic leukemia
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Tretinoin Gastroenterology Leukocyte Count Leukemia Promyelocytic Acute Internal medicine medicine Humans Age of Onset neoplasms Retrospective Studies Chemotherapy Hematology Leukopenia business.industry organic chemicals Syndrome Middle Aged medicine.disease biological factors Surgery Lymphoma Retinoic acid syndrome Leukemia Treatment Outcome Oncology Female medicine.symptom Complication business |
| Zdroj: | Leukemia. 17(2) |
| ISSN: | 0887-6924 |
| Popis: | Treatment combining ATRA and chemotherapy (CT) has improved the outcome of APL patients, by comparison with CT alone. ATRA syndrome is a life-threatening complication of ATRA treatment whose prophylaxis remains somewhat controversial. In APL93 trial, newly diagnosed APL patients/=65 years and with initial WBC counts below 5000/mm(3) were randomized between ATRA until CR achievement followed by CT (ATRA --CT) and ATRA with early addition of CT, on day 3 of ATRA treatment (ATRA + CT). The incidence of ATRA syndrome in the ATRA --CT arm was 18% (22/122) as compared to 9.2% (17/184) in the ATRA + CT arm (P = 0.035). In the ATRA --CT arm, three (2.5%) patients died from ATRA syndrome, as compared to one (0.5%) in the ATRA + CT group. Early addition of chemotherapy to ATRA in newly diagnosed APL with low WBC counts significantly reduced the incidence of ATRA syndrome. |
| Databáze: | OpenAIRE |
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