Dynamic control of neurochemical release with ultrasonically-sensitive nanoshell-tethered liposomes
| Autor: | Brian I. Hyland, Sean M. Mackay, Guy N. L. Jameson, David Mo Aung Myint, Richard A. Easingwood, Eng Wui Tan, Dylan Hegh, John N. J. Reynolds, Jeffery R. Wickens |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Liposome
Materials science Therapeutic ultrasound medicine.medical_treatment Stimulation 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Controlled release Nanoshell 0104 chemical sciences lcsh:Chemistry lcsh:QD1-999 Drug delivery Materials Chemistry medicine Biophysics Environmental Chemistry Nanocarriers Surface plasmon resonance 0210 nano-technology |
| Zdroj: | Communications Chemistry, Vol 2, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2399-3669 |
| Popis: | The unique surface plasmon resonance of hollow gold nanoshells can be used to achieve drug release from liposomes upon laser stimulation, and adapted to mimic the intricate dynamics of neurotransmission ex vivo in brain preparations. However, to induce a physiological response in vivo requires the degree of temporal precision afforded by laser stimulation, but with a greater depth of penetration through tissue. Here we report that the attachment of hollow gold nanoshells to the surface of robust liposomes results in a construct that is highly sensitive to ultrasonic stimulation. The resulting construct can be remotely triggered by low intensity, therapeutic ultrasound. To our knowledge, this is the first example of nanoparticle-liposome system that can be activated by both laser and acoustic stimulation. The system is capable of encapsulating the neurochemical dopamine, and repeatedly releasing small amounts on-demand in a circulating environment, allowing for precise spatiotemporal control over the release profile. Nanoscale materials hold promising applications for controlled release of bioactive compounds. Here hollow gold nanoshells tethered to liposomes allows the controlled release of encapsulated neurochemicals by acoustic or laser stimulation |
| Databáze: | OpenAIRE |
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