Anticipatory pleasure predicts effective connectivity in the mesolimbic system
| Autor: | Zhi eLi, Chao eYan, Wei-zhen eXie, Ke eLi, Ya-wei eZeng, Zhen eJin, Eric F. C. Cheung, Raymond C. K. Chan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Anticipatory pleasure
hedonic capacity Cognitive Neuroscience media_common.quotation_subject Thalamus Mesolimbic pathway 050105 experimental psychology Pleasure lcsh:RC321-571 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine 0501 psychology and cognitive sciences Right nucleus accumbens dynamic causal modeling lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research media_common monetary reward nucleus accumbens (NAcc) 05 social sciences Anticipation Ventral tegmental area Right thalamus Neuropsychology and Physiological Psychology medicine.anatomical_structure Psychology Monetary incentive delay task Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Behavioral Neuroscience, Vol 9 (2015) Frontiers in Behavioral Neuroscience |
| ISSN: | 1662-5153 |
| DOI: | 10.3389/fnbeh.2015.00217/full |
| Popis: | Convergent evidence suggests the important role of the mesolimbic pathway in anticipating monetary rewards. However, the underlying mechanism of how the sub-regions interact with each other is still not clearly understood. Using dynamic causal modeling, we constructed a reward-related network for anticipating monetary reward using the Monetary Incentive Delay Task. Twenty-six healthy adolescents (Female/Male = 11/15; age = 18.69±1.35 years; education = 12±1.58 years) participated in the present study. The best-fit network involved the right substantia nigra/ventral tegmental area, the right nucleus accumbens and the right thalamus, which were all activated during anticipation of monetary gain and loss. The substantia nigra/ventral tegmental area directly activates the nucleus accumbens and the thalamus. More importantly, monetary gain modulated the connectivity from the substantia nigra/ventral tegmental area to the nucleus accumbens and this was significantly correlated with subjective anticipatory pleasure (r = 0.649, p < 0.001). Our findings suggest that activity in the mesolimbic pathway during the anticipation of monetary reward could to some extent be predicted by subjective anticipatory pleasure. |
| Databáze: | OpenAIRE |
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