Trajectories of Vasomotor Symptoms and Carotid Intima Media Thickness in the Study of Women’s Health Across the Nation
| Autor: | Daniel S. McConnell, Winifred Rossi, Hsiang-Yu Chen, Lynda H. Powell, Elizabeth A. Jackson, Sherry Sherman, Rebecca C. Thurston, Marcia G. Ory, Susan R. Johnson, Gail A. Greendale, Appendix, Carol A. Derby, Sonja McKinlay, Hadine Joffe, Samar R. El Khoudary, MaryFran Sowers, Siobán D. Harlow, Nanette Santoro, Chris Gallagher, Robert M. Neer, Rachel P. Wildman, Ping G. Tepper, Joel S. Finkelstein, Ellen B. Gold, Karen A. Matthews, Maria M. Brooks, Gerson Weiss, Kim Sutton-Tyrrell, Howard M. Kravitz |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Disease 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Epidemiology medicine Humans Longitudinal Studies Prospective Studies Prospective cohort study Subclinical infection Advanced and Specialized Nursing 030219 obstetrics & reproductive medicine Vasomotor business.industry Middle Aged medicine.disease United States Surgery Postmenopause Vasomotor System Menopause Intima-media thickness Cardiovascular Diseases Women's Health Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Demography Cohort study |
| Zdroj: | Stroke. 47:12-17 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and Purpose— Emerging work has linked menopausal vasomotor symptoms (VMS) to subclinical cardiovascular disease (CVD) among women. However, VMS are dynamic over time. No studies have considered how temporal patterns of VMS may relate to subclinical CVD. We tested how temporal patterns of VMS assessed over 13 years were related to carotid intima media thickness (IMT) among midlife women. Methods— The Study of Women’s Health Across the Nation is a longitudinal cohort study of midlife women. Eight hundred and eleven white, black, Hispanic, and Chinese participants with a well-characterized final menstrual period completed measures of VMS, a blood draw, and physical measures approximately annually for 13 years. Women underwent a carotid artery ultrasound at study visit 12. Results— Four trajectories of VMS were identified by trajectory analysis (consistently high, early-onset, late-onset, persistently low VMS) and tested in relation to carotid indices in linear regression models. Results indicated that women with early-onset VMS had both greater mean IMT (beta, b [standard error, SE]=0.03 [0.01], P =0.03) and greater maximal IMT (b [SE]=0.04 [0.01], P =0.008) than women with consistently low VMS, adjusting for demographics and CVD risk factors. Conclusions— This is the first study to test trajectories of VMS in relation to subclinical CVD. Women with VMS early in the menopause transition had higher mean IMT and maximal IMT than those with consistently low VMS across the transition. Associations were not accounted for by demographic factors nor by CVD risk factors. Results can signal to women in need of early CVD risk reduction. |
| Databáze: | OpenAIRE |
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