Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks
| Autor: | Chuanyun Xu, Jan H. Lui, Liqun Luo, Zhigang He, Mark J. Wagner, Stephen R. Quake, Yuanyuan Liu, Ellen C. Gingrich, Daniel T. Pederick |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Receptors Peptide Computer science Nerve Tissue Proteins Hippocampal formation Ligands Hippocampus Article Mice Neural Pathways Animals Entorhinal Cortex CA1 Region Hippocampal Physics Membrane Glycoproteins Multidisciplinary Extramural Membrane Proteins Axons Axon Guidance nervous system Female Axon guidance Transcriptome Neuroscience Reciprocal |
| Zdroj: | Science |
| DOI: | 10.1101/2020.05.28.122242 |
| Popis: | Parallel information processing is a salient feature of complex nervous systems. For example, the medial and lateral hippocampal networks (MHN and LHN) preferentially process spatial- and object-related information, respectively. However, the mechanisms underlying parallel network assembly during development remain largely unknown. Here, we show that complementary expression of cell-surface molecules Teneurin-3 (Ten3) and Latrophilin-2 (Lphn2) in the MHN and LHN, respectively, guides the precise assembly of both the MHN and LHN. Viral-genetic perturbations in vivo demonstrate that Ten3+ axons are repelled by target-derived Lphn2, revealing that Lphn2/Ten3-mediated repulsion and Ten3/Ten3-mediated attraction cooperate to control precise target selection of MHN axons. In the LHN, Lphn2+ axons are confined to Lphn2+ targets via repulsion from Ten3+ targets. Our findings demonstrate that assembly of parallel hippocampal networks follows a ‘Ten3→Ten3, Lphn2→Lphn2’ rule instructed by reciprocal repulsions. |
| Databáze: | OpenAIRE |
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