Effects of Octenidine on Dental Plaque and Gingivitis in Monkeys
| Autor: | John B. Kennedy, Dale B. Mirth, R.J. Shern, Wayne A. Little |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Baseline values
Pyridines business.industry Dental Plaque Index Dental Plaque Mouthwashes Placebo treatment Dentistry Dental plaque medicine.disease Placebo Gingivitis Gingival index Macaca fascicularis Reference Values medicine Oral rinses Animals Periodontics Imines Periodontal Index medicine.symptom Subgingival plaque business |
| Zdroj: | Journal of Periodontology. 58:628-633 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.1987.58.9.628 |
| Popis: | This investigation monitored the effects of daily oral rinses with octenidine on plaque and gingivitis in five monkeys. Formulations containing 0.5% or 1.0% octenidine or the rinse vehicle placebo were provided daily for 2 weeks. Each week the dentition of each monkey was examined, photographed, and sampled for plaque. All responses exhibited a numerical decrease in mean scores following treatments with each concentration of octenidine, whereas the placebo treatment exerted negligible effects. Decreases in plaque mass were observed after 2 weeks of treatment with 1% octenidine (58%) or 0.5% octenidine (55%) compared with the corresponding baseline values. Similar trends were noted in the extent and thickness of supragingival plaque and its ability to decrease the pH of a sucrose solution. Octenidine treatments reduced the proportions of motile forms in samples of subgingival plaque and also restricted its ability to produce H2S. Slight numerical decreases were seen in the Gingival Index and flow rate of the crevicular fluid. These consistent protective trends suggest that octenidine decreases the pathogenic potential of established plaque. |
| Databáze: | OpenAIRE |
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