Central pain processing in chronic chemotherapy-induced peripheral neuropathy: a functional magnetic resonance imaging study

Autor: Dinesh Selvarajah, John A. Snowden, Solomon Tesfaye, Elaine G. Boland, Yousef Ezaydi, Iain D. Wilkinson, Sam H Ahmedzai, Mike D. Hunter
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Pathology
Epidemiology
Cancer Treatment
Precuneus
lcsh:Medicine
Plasma Cell Disorders
Diagnostic Radiology
Hematologic Cancers and Related Disorders
Medicine and Health Sciences
Clinical Epidemiology
lcsh:Science
Multiple myeloma
Pain Measurement
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Palliative Care
Temperature
Peripheral Nervous System Diseases
Hematology
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
Oncology
Chemotherapy-induced peripheral neuropathy
Research Design
Neuropathic pain
Cardiology
Female
Multiple Myeloma
Research Article
medicine.medical_specialty
Clinical Research Design
Analgesic
Pain
Research and Analysis Methods
Insular cortex
Diagnostic Medicine
Physical Stimulation
Internal medicine
medicine
Humans
Myelomas and Lymphoproliferative Diseases
Aged
business.industry
lcsh:R
Cancers and Neoplasms
medicine.disease
Neurophysiological Monitoring
Health Care
Peripheral neuropathy
Quality of Life
lcsh:Q
business
Functional magnetic resonance imaging
Zdroj: PLoS ONE, Vol 9, Iss 5, p e96474 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: Life expectancy in multiple myeloma has significantly increased. However, a high incidence of chemotherapy induced peripheral neuropathy (CIPN) can negatively influence quality of life during this period. This study applied functional magnetic resonance imaging (fMRI) to compare areas associated with central pain processing in patients with multiple myeloma who had chemotherapy induced peripheral neuropathy (MM-CIPN) with those from healthy volunteers (HV). Twenty-four participants (n = 12 MM-CIPN, n = 12 HV) underwent Blood Oxygen Level-Dependent (BOLD) fMRI at 3T whilst noxious heat-pain stimuli were applied to the foot and then thigh. Patients with MM-CIPN demonstrated greater activation during painful stimulation in the precuneus compared to HV (p = 0.014, FWE-corrected). Patients with MM-CIPN exhibited hypo-activation of the right superior frontal gyrus compared to HV (p = 0.031, FWE-corrected). Significant positive correlation existed between the total neuropathy score (reduced version) and activation in the frontal operculum (close to insular cortex) during foot stimulation in patients with MM-CIPN (p = 0.03, FWE-corrected; adjusted R2 = 0.87). Painful stimuli delivered to MM-CIPN patients evoke differential activation of distinct cortical regions, reflecting a unique pattern of central pain processing compared with healthy volunteers. This characteristic activation pattern associated with pain furthers the understanding of the pathophysiology of painful chemotherapy induced peripheral neuropathy. Functional MRI provides a tool for monitoring cerebral changes during anti-cancer and analgesic treatment.
Databáze: OpenAIRE
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