Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine
| Autor: | Christopher E Lopez, Kevin L. Legge |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
viruses Immunology T cells lcsh:Medicine Review medicine.disease_cause Antigenic drift Virus influenza virus 03 medical and health sciences 0302 clinical medicine Immunity vaccine antibody Drug Discovery Pandemic Influenza A virus Medicine Live attenuated influenza vaccine Pharmacology (medical) Pharmacology business.industry lcsh:R virus diseases adaptive immunity Acquired immune system Virology Vaccination 030104 developmental biology Infectious Diseases business 030215 immunology |
| Zdroj: | Vaccines, Vol 8, Iss 434, p 434 (2020) Vaccines |
| Popis: | Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. Despite being an important countermeasure to combat influenza virus and being highly efficacious when matched to circulating influenza viruses, current preventative strategies of vaccination against influenza virus often provide incomplete protection due the continuous antigenic drift/shift of circulating strains of influenza virus. Prevention and control of influenza virus infection with vaccines is dependent on the host immune response induced by vaccination and the various vaccine platforms induce different components of the local and systemic immune response. This review focuses on the immune basis of current (inactivated influenza vaccines (IIV) and live attenuated influenza vaccines (LAIV)) as well as novel vaccine platforms against influenza virus. Particular emphasis will be placed on how each platform induces cross-protection against heterologous influenza viruses, as well as how this immunity compares to and contrasts from the “gold standard” of immunity generated by natural influenza virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|