Fishing anti(lymph)angiogenic drugs with zebrafish
| Autor: | Manuel Marí-Beffa, Miguel Ángel Medina, Ana R. Quesada, Melissa García-Caballero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug animal structures Angiogenesis media_common.quotation_subject Drug Evaluation Preclinical Angiogenesis Inhibitors Pharmacology Biology 03 medical and health sciences In vivo Drug Discovery Animals Humans Lymphangiogenesis Zebrafish media_common Neovascularization Pathologic fungi biology.organism_classification 030104 developmental biology Lymphatic system embryonic structures Models Animal Cancer research Fish Lymph Neovascularización |
| Zdroj: | RIUMA. Repositorio Institucional de la Universidad de Málaga instname |
| Popis: | Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph) angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays. Our experimental work was supported by grants BIO2014-56092-R (Spanish Ministry of Economy and Competitiveness and FEDER), and PIE P12-CTS-1507,CVI-6585 and funds from group BIO-267 (Andalucian Government and FEDER). CIBER de Enfermedades Raras and CIBER de Bioingenierı´a, Biomateriales y Nanomedicina are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Databáze: | OpenAIRE |
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