Ewing's Sarcoma of the Axial System in Patients Older Than 15 Years: Dismal Prognosis Despite Intensive Multiagent Chemotherapy and Aggressive Local Treatment
| Autor: | Sevil Bavbek, Emin Darendeliler, Andac Argon, Yavuz Dizdar, Hakan Camlica, Fulya Yaman, Mert Basaran, Haluk Onat, Burak Sakar, Harzem Ozger |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Adolescent Bone Neoplasms Sarcoma Ewing Drug Administration Schedule Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Ifosfamide Progression-free survival Cyclophosphamide Survival rate Etoposide Retrospective Studies business.industry Ewing's sarcoma Induction chemotherapy General Medicine Prognosis medicine.disease Chemotherapy regimen Surgery Survival Rate Doxorubicin Vincristine Multivariate Analysis Female Sarcoma business medicine.drug |
| Zdroj: | Japanese Journal of Clinical Oncology. 34:667-672 |
| ISSN: | 1465-3621 |
| Popis: | BACKGROUND Older age and axial location of Ewing's sarcoma have been reported as unfavorable prognostic factors. METHODS The records of patients older than 15 years with the Ewing's family of tumors were reviewed retrospectively. After the induction chemotherapy consisting of alternating vincristine, adriablastin, cyclophosphamide (VAC) and etoposide, ifosfamide with mesna protection (IE), a local treatment modality was chosen based on tumor and patient characteristics. RESULTS Twenty-five patients with a median age of 19 years were evaluated. Median follow-up was 26 months (range 4-58). Seventeen patients (68%) had died. In univariate analysis, factors predictive of shorter survival were the patients presenting with metastatic disease, with the primary tumor located at the pelvis, those who never achieved complete response to chemotherapy and those who had chemotherapy for |
| Databáze: | OpenAIRE |
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