Children with cerebral palsy have altered oscillatory activity in the motor and visual cortices during a knee motor task
| Autor: | Elizabeth Heinrichs-Graham, Max J. Kurz, James E. Gehringer, Tony W. Wilson, Amy L. Proskovec |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Adolescent Vision Cognitive Neuroscience Inferior frontal gyrus Motor Activity lcsh:Computer applications to medicine. Medical informatics lcsh:RC346-429 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Beta Rhythm Knee Isometric Cortical Synchronization Child lcsh:Neurology. Diseases of the nervous system Visual Cortex Lower extremity medicine.diagnostic_test Supplementary motor area Cerebral Palsy 05 social sciences Motor Cortex Magnetoencephalography Inferior parietal lobule Regular Article Alpha Rhythm medicine.anatomical_structure Visual cortex Neurology lcsh:R858-859.7 Female Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery Psychomotor Performance Motor cortex |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 15, Iss, Pp 298-305 (2017) |
| ISSN: | 2213-1582 |
| Popis: | The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying structural aberrations within the white matter (e.g., fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of motor actions. The current investigation used high-density magnetoencephalography to begin to fill this knowledge gap by quantifying the temporal dynamics of the alpha and beta cortical oscillations in children with CP (age = 15.5 ± 3 years; GMFCS levels II–III) and typically developing (TD) children (age = 14.1 ± 3 years) during a goal-directed isometric target-matching task using the knee joint. Advanced beamforming methods were used to image the cortical oscillations during the movement planning and execution stages. Compared with the TD children, our results showed that the children with CP had stronger alpha and beta event-related desynchronization (ERD) within the primary motor cortices, premotor area, inferior parietal lobule, and inferior frontal gyrus during the motor planning stage. Differences in beta ERD amplitude extended through the motor execution stage within the supplementary motor area and premotor cortices, and a stronger alpha ERD was detected in the anterior cingulate. Interestingly, our results also indicated that alpha and beta oscillations were weaker in the children with CP within the occipital cortices and visual MT area during movement execution. These altered alpha and beta oscillations were accompanied by slower reaction times and substantial target matching errors in the children with CP. We also identified that the strength of the alpha and beta ERDs during the motor planning and execution stages were correlated with the motor performance. Lastly, our regression analyses suggested that the beta ERD within visual areas during motor execution primarily predicted the amount of motor errors. Overall, these data suggest that uncharacteristic alpha and beta oscillations within visuomotor cortical networks play a prominent role in the atypical motor actions exhibited by children with CP. Highlights • Children with CP performed an isometric task with the knee joint. • Children with CP had stronger alpha and beta ERD during motor planning. • These ERD differences extended through the motor execution period. • Occipital cortices and visual MT area alpha and beta ERD were weaker. • Altered alpha and beta ERD were accompanied by impaired motor actions. |
| Databáze: | OpenAIRE |
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