The microRNA let-7b-5p Is Negatively Associated with Inflammation and Disease Severity in Multiple Sclerosis
| Autor: | Francesca De Santa, Francesca Romana Rizzo, Ettore Dolcetti, Monica Nencini, Valerio Licursi, Silvia Caioli, Colleen P. Ryan, Antonio Bruno, Sara Balletta, Chiara Castelli, Antonietta Gentile, Luana Gilio, Silvia Bullitta, Krizia Sanna, Diego Fresegna, Georgia Mandolesi, Livia Guadalupi, Fabio Buttari, Annamaria Finardi, Alessandra Musella, Alessandro Moscatelli, Diego Centonze, Francesca De Vito, Carlo Presutti, Mario Stampanoni Bassi, Roberto Furlan, Valentina Vanni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Multiple Sclerosis Inflammation Disease Settore MED/26 Expanded Disability Status Scale (EDSS) Article RANTES Cerebrospinal fluid Disease severity let-7 microRNA progressive multiple sclerosis (PMS) medicine Humans lcsh:QH301-705.5 business.industry Multiple sclerosis General Medicine Middle Aged medicine.disease IL5 Peripheral MicroRNAs multiple sclerosis (MS) lcsh:Biology (General) inflammation Immunology miRNAs G_CSF Biomarker (medicine) Female medicine.symptom business |
| Zdroj: | Cells, Vol 10, Iss 330, p 330 (2021) Cells Volume 10 Issue 2 |
| ISSN: | 2073-4409 |
| Popis: | The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention in the field of multiple sclerosis (MS) research but it is still in its infancy. In the present study, we observed in a large sample of MS patients that let-7b-5p levels in the cerebrospinal fluid (CSF) were highly correlated with a number of microRNAs implicated in MS, as well as with a variety of inflammation-related protein factors, showing specific expression patterns coherent with let-7b-5p-mediated regulation. Additionally, we found that the CSF let-7b-5p levels were significantly reduced in patients with the progressive MS compared to patients with relapsing-remitting MS and were negatively correlated with characteristic hallmark processes of the two phases of the disease. Indeed, in the non-progressive phase, let-7b-5p inversely associated with both central and peripheral inflammation whereas, in progressive MS, the CSF levels of let-7b-5p negatively correlated with clinical disability at disease onset and after a follow-up period. Overall, our results uncovered, by the means of a multidisciplinary approach and multiple statistical analyses, a new possible pleiotropic action of let-7b-5p in MS, with potential utility as a biomarker of MS course. |
| Databáze: | OpenAIRE |
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